PEPTIDE RECEPTOR RADIONUCLIDE THERAPY

PRRNT in neuroendocrine tumors

Procedure description:

PRRNT is a molecularly targeted radiation therapy involving the systemic administration of a radiolabelled peptide designed to target with high affinity and specificity receptors over-expressed on tumors. It is used to target metastatic or inoperable neuroendocrine tumors expressing the somatostatin receptor sub-type 2.

Indications:

  • PRRNT is indicated for the treatment of patients with positive expression of SSTR2, or metastatic, or inoperable NET.

  • Patients candidate for treatment are mainly those with SSTR2 expressing NET of the gastroenteropancreatic and bronchial tracts and may also include patients with phaeochromocytoma, paraganglioma, neuroblastoma, or medullary thyroid carcinoma, especially those with well-differentiated and moderately differentiated NET grade 1 or 2.